Indirect measures of associations and psychopathology: applications to Spider Phobia

To study of cognitive fear networks and associations, indirect experimental paradigms like the Implicit Association Test (IAT, Greenwald et al., 1998) or the Extrinsic Affective Simon Task (EAST, De Houwer, 2003) may be helpful, as they promise to assess the structure of specific associations using a performance based approach without having to ask the participant for a verbal report. Three studies investigated the usefulness and characteristics of IAT and EAST. The aim of the first study was to measure fear associations towards spiders among spider phobic and non-phobic participants as well as in a group of spider enthusiasts. Results indicate that the IAT paradigm is sensitive to the strength of fear relevant associations and able to predict anxious behavior beyond the predictions of direct measures such as questionnaires. The second study focused on some of the mechanisms that underlie IAT effects. With a newly developed masked IAT, these experiments investigated the influences of individual stimuli and superordinate categories on IAT performance. Besides theoretical implications, the results also provide practical, relevant applications for the use of IAT experiments. A third study applied the EAST to investigate how different context conditions lead to differential activation of cognitive schemata in fear of spiders. One can conclude that the impact of automatic threat associations depends on the activated context, and that the EAST is suitable for the assessment of fear associations and their current activation level. This dissertation leads to the conclusion that the performance based methodology of the IAT and EAST is a useful and practical approach to reflect fear associations in phobia indirectly. At this point, the use of indirect measures is still at its beginning, and requires intensive methodological and theoretical efforts. These paradigms, however, may become useful for possible implications in psychopathology and other fields of psychology

Analyzing the Effects of Role Configuration in Logistics Processes using Multiagent-Based Simulation: An Interdisciplinary Approach

Current trends like the digital transformation and Industry 4.0 are challenging logistics management: flexible process development and optimization has been a primary concern in research in the last two decades. However, flexibility is limited by its underlying distribution of action and task knowledge. Thus, our objective is to develop an approach to optimize performance of logistics processes by dynamic (re-) configuration of knowledge in teams. One of the key assumptions for that approach is, that the distribution of knowledge has impact on team‘s performance. Consequently, we propose a formal specification for representing active resources (humans or smart machines) and distribution of action knowledge in multiagent-based simulation. In the second part of this paper, we analyze process quality in a psychologically validated laboratory case study. Our simulation results support our assumption, i.e., the results show that there is significant influence of knowledge distribution on process quality

The Activation Status of Neuroantigen-specific T Cells in the Target Organ Determines the Clinical Outcome of Autoimmune Encephalomyelitis

The clinical picture of experimental autoimmune encephalomyelitis (EAE) is critically dependent on the nature of the target autoantigen and the genetic background of the experimental animals. Potentially lethal EAE is mediated by myelin basic protein (MBP)–specific T cells in Lewis rats, whereas transfer of S100β- or myelin oligodendrocyte glycoprotein (MOG)–specific T cells causes intense inflammatory response in the central nervous system (CNS) with minimal disease. However, in Dark Agouti rats, the pathogenicity of MOG-specific T cells resembles the one of MBP-specific T cells in the Lewis rat. Using retrovirally transduced green fluorescent T cells, we now report that differential disease activity reflects different levels of autoreactive effector T cell activation in their target tissue. Irrespective of their pathogenicity, the migratory activity, gene expression patterns, and immigration of green fluorescent protein+ T cells into the CNS were similar. However, exclusively highly pathogenic T cells were significantly reactivated within the CNS. Without local effector T cell activation, production of monocyte chemoattractants was insufficient to initiate and propagate a full inflammatory response. Low-level reactivation of weakly pathogenic T cells was not due to anergy because these cells could be activated by specific antigen in situ as well as after isolation ex vivo

Abortive Lytic Reactivation of KSHV in CBF1/CSL Deficient Human B Cell Lines

Since Kaposi's sarcoma associated herpesvirus (KSHV) establishes a persistent infection in human B cells, B cells are a critical compartment for viral pathogenesis. RTA, the replication and transcription activator of KSHV, can either directly bind to DNA or use cellular DNA binding factors including CBF1/CSL as DNA adaptors. In addition, the viral factors LANA1 and vIRF4 are known to bind to CBF1/CSL and modulate RTA activity. To analyze the contribution of CBF1/CSL to reactivation in human B cells, we have successfully infected DG75 and DG75 CBF1/CSL knock-out cell lines with recombinant KSHV.219 and selected for viral maintenance by selective medium. Both lines maintained the virus irrespective of their CBF1/CSL status. Viral reactivation could be initiated in both B cell lines but viral genome replication was attenuated in CBF1/CSL deficient lines, which also failed to produce detectable levels of infectious virus. Induction of immediate early, early and late viral genes was impaired in CBF1/CSL deficient cells at multiple stages of the reactivation process but could be restored to wild-type levels by reintroduction of CBF1/CSL. To identify additional viral RTA target genes, which are directly controlled by CBF1/CSL, we analyzed promoters of a selected subset of viral genes. We show that the induction of the late viral genes ORF29a and ORF65 by RTA is strongly enhanced by CBF1/CSL. Orthologs of ORF29a in other herpesviruses are part of the terminase complex required for viral packaging. ORF65 encodes the small capsid protein essential for capsid shell assembly. Our study demonstrates for the first time that in human B cells viral replication can be initiated in the absence of CBF1/CSL but the reactivation process is severely attenuated at all stages and does not lead to virion production. Thus, CBF1/CSL acts as a global hub which is used by the virus to coordinate the lytic cascade

Arbeitsplatz der Zukunft: Herausforderungen und Chancen altersgemischter Zusammenarbeit

Der demografische Wandel wird auch die Arbeitsstrukturen und -prozesse in Unternehmen und Organisationen verändern. Welche Chancen und Risiken birgt eine altersgemischte Zusammenarbeit? Welche Bedeutung hat eine altersgerechte Führung für Leistung, Gesundheit und Wohlempfinden der Belegschaft? Was müssen Unternehmen und Mitarbeitende beachten, damit das Potenzial verschiedener Generationen genutzt werden kann? Ausgehend von arbeitspsychologischen Theorien werden in der Vorlesung aktuelle Forschungsergebnisse und Ansätze aus der Praxis vorgestellt

Indirect measures of associations and psychopathology: applications to Spider Phobia

To study of cognitive fear networks and associations, indirect experimental paradigms like the Implicit Association Test (IAT, Greenwald et al., 1998) or the Extrinsic Affective Simon Task (EAST, De Houwer, 2003) may be helpful, as they promise to assess the structure of specific associations using a performance based approach without having to ask the participant for a verbal report. Three studies investigated the usefulness and characteristics of IAT and EAST. The aim of the first study was to measure fear associations towards spiders among spider phobic and non-phobic participants as well as in a group of spider enthusiasts. Results indicate that the IAT paradigm is sensitive to the strength of fear relevant associations and able to predict anxious behavior beyond the predictions of direct measures such as questionnaires. The second study focused on some of the mechanisms that underlie IAT effects. With a newly developed masked IAT, these experiments investigated the influences of individual stimuli and superordinate categories on IAT performance. Besides theoretical implications, the results also provide practical, relevant applications for the use of IAT experiments. A third study applied the EAST to investigate how different context conditions lead to differential activation of cognitive schemata in fear of spiders. One can conclude that the impact of automatic threat associations depends on the activated context, and that the EAST is suitable for the assessment of fear associations and their current activation level. This dissertation leads to the conclusion that the performance based methodology of the IAT and EAST is a useful and practical approach to reflect fear associations in phobia indirectly. At this point, the use of indirect measures is still at its beginning, and requires intensive methodological and theoretical efforts. These paradigms, however, may become useful for possible implications in psychopathology and other fields of psychology

Evidence for the Dispersed Leadership Theory in Teams: A Policy-Capturing Study

Based on the Dispersed Leadership Theory in Teams, we examined the simultaneous influence of three factors on team members’ attitudes and behavior: (1) interactional leadership carried out by leaders, (2) team leadership performed by team members, and (3) structural leadership exerted by work and organizational structures. Results from two policycapturing studies revealed that structural, interactional and team leadership simultaneously affect an individual’s behavior in terms of task behavior, task performance and commitment. Results also indicated that the need for dispersed leadership was particularly high in situations with high task uncertainty and where the learning of new task behavior was required. Results from Study 2 further demonstrated the positive relationship between interactional leadership, team leadership, and structural leadership with team members’ task performance and commitment. Taken together, these findings provide evidence for the Dispersed Leadership Theory in Teams which showed a way to structure and extend future leadership research

Ability self-concept and self-efficacy in higher education: An empirical differentiation based on their factorial structure.

Ability self-concept (SC) and self-efficacy (SE) are central competence-related self-perceptions that affect students' success in educational settings. Both constructs show conceptual differences but their empirical differentiation in higher education has not been sufficiently demonstrated. In the present study, we investigated the empirical differentiation of SC and SE in higher education with N = 1,243 German psychology students (81% female; age M = 23.62 years), taking into account central methodological requirements that, in part, have been neglected in prior studies. SC and SE were assessed at the same level of specificity, only cognitive SC items were used, and multiple academic domains were considered. We modeled the structure of SC and SE taking into account a multidimensional and/or hierarchical structure and investigated the empirical differentiation of both constructs on different levels of generality (i.e., domain-specific and domain-general). Results supported the empirical differentiation of SC and SE with medium-sized positive latent correlations (range r = .57 - .68) between SC and SE on different levels of generality. The knowledge about the internal structure of students' SC and SE and the differentiation of both constructs can help us to develop construct-specific and domain-specific intervention strategies. Future empirical comparisons of the predictive power of SC and SE can provide further evidence that both represent empirical different constructs

Measurement of team knowledge in the field: Methodological advantages and limitations

Team knowledge is seen as an important element in the understanding of coordination processes in teams. Congruent with the taxonomy of coordination mechanisms (cf. Chaps. 2 and 7), the construct of team knowledge refers to shared team-level knowledge structures facilitating implicit processes such as tacit behaviours as well as coordination success. This chapter answers three major questions: (1) What are the challenges of measuring team knowledge in organizational settings compared to more controlled laboratory settings? (2) What concepts of team knowledge exist in the psychological literature, and how are they related to coordination processes? (3) What methods can be applied to measure team knowledge in the field? Although there are several approaches to identifying and measuring team knowledge in a laboratory setting, applications in an organizational context are rare. Thus, this chapter discusses three types of team knowledge: team mental models, team situation models, and transactive memory systems. The advantages and limitations of techniques for capturing team knowledge are discussed and current directions are introduced